Active Motif,
Tools to analyze nuclear function,
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High Sensitivity ChIP for the Most

Challenging Targets and Samples

ChIP-IT® High Sensitivity provides great ChIP results, even with
difficult-to-ChIP materials, such as low abundance transcription
factors, low-affinity antibodies or limited amounts of starting material.

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DNA Methylation Antibodies

Active Motif offers a large variety of highly
validated antibodies for the study of
DNA methylation in all its forms, including
antibodies against 5-mC, 5-hmC, 5-fC,
5-caC, 3-mC, and a number of DNMTs.

See our DNA Methylation Antibodies
DNA Methylation Antibodies

Transcription Factor Assays

TransAM® Kits are DNA-binding assays that facilitate
the study of transcription factor activation in mammalian
tissue and cell culture extracts. TransAM has
been cited in over 800 papers, making
it the overwhelming method of choice.

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TransAM DNA-binding ELISAs

Study miRNA-3´UTR Interactions

The LightSwitch™ 3´UTR Reporter Collection includes
over 12,000 3´UTRs cloned from the human genome into
ready-to-transfect reporter vectors. Combined with our large
collections of miRNA Mimics and Inhibitors, you have
everything needed to study miRNA-3´UTR interactions.

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LightSwitch 3'UTR-miRNA Interactions

MODified™ Histone Peptide Array

Screen antibodies, enzymes and proteins for
binding interactions with histones and 59 specific
acetylation, methylation, phosphorylation and
citrullination modifications. With up to 4 modifications
per peptide, 384 different combinations are included.

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MODified Histone Peptide Array

Next-Gen Sequencing of

Methylated DNA

Active Motif's MeDIP and MethylCollector™ Ultra Kits
specifically enrich for methylated DNA fragments that are
ideal for use in MeDIP-Seq and MIRA-Seq.

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Next-Gen of Enriched Methylated DNA

ReNucs: Recombinant Nucleosomes

New Products for Epigenetics Research

  • Low Cell ChIP-Seq Kit Now Available

    Obtain high quality histone and transcription factor ChIP-Seq data from as few as 1,000 cells using Active Motif's Low Cell ChIP-Seq Kit. Complete ChIP-Seq workflow includes reagents for chromatin preparation, immunoprecipitation and NGS library preparation that have been optimized for use on limited cell numbers. More >

  • AbFlex™ Recombinant Antibodies (rAb)

    Active Motif's unique AbFlex™ Recombinant Antibodies are generated from defined DNA sequences ensuring consistency and specificity across antibody lots. AbFlex antibodies contain three molecular tags for flexible, site-specific labeling and purification options. More >

  • Sortag-IT™ Antibody Labeling Kits

    The Sortag-IT™ Labeling Kits are designed for use in combination with Active Motif's AbFlex™ Recombinant Antibodies. Easily attach a variety of labels including fluorophores, enzymes (AP, HRP), biotin, DNA, peptides or other labels directly to the antibody via the Sortase recognition sequence. More >

  • FFPE Bisulfite Conversion Kit

    The FFPE Bisulfite Conversion Kit is designed for the analysis of DNA methylation profiles in FFPE tissue sections. It offers the advantage of providing optimized reagents throughout the workflow to improve recovery of high quality DNA, minimize degradation and provide greater than 99% conversion efficiency. More >

  • enChIP Kit to Confirm CRISPR/Cas9 Specificity

    The enChIP Kit uses the CRISPR/Cas9 system to direct a guide RNA (gRNA) and AM-tagged dCas9 protein to a specific genomic locus for immunoprecipitation. enChIP can be used to identify off-target binding effects. More >

  • Quantify Global Changes in 5-hmC

    The Global 5-hmC Quantification Kit is an ELISA-based assay designed to screen for differences in global 5-hydroxymethylcytosine (5-hmC) levels across samples or treatment conditions. The included DNA standards provide quantitative results that are consistent with mass spectrometry. More >

  • Specific Isolation of Nuclear and Cytoplasmic RNA

    The RNA Subcellular Isolation Kit makes it easier to study low abundance RNA transcripts and to demonstrate the role of lncRNA localization with RNA function by providing an efficient method to isolate nuclear or cytoplasmic RNA fractions without cross-contamination. More >

  • Perform ChIP Without Protein-specific Antibodies

    The Tag-ChIP-IT® Kit makes it easy to perform ChIP with transcription factor sequence variants, mutations or truncations by eliminating the need for protein-specific antibodies. Simply clone your protein sequence with Active Motif's unique AM-tag, specifically designed for use in ChIP, transfect your cells and perform ChIP using an antibody directed against the AM-tag. More >

  • Promoter Reporters Validated Using Pathway-specific Inductions

    The LightSwitch™ Validated Pathway Collections contain promoter reporter constructs that were experimentally validated to show significant activation or repression in response to pathway-specific induction conditions, so they are ideal for studying the key promoters that regulate a variety of different pathways, such as inflammation, hypoxia, DNA damage, heat shock, etc. More >

  • Reduce the Effects of Technical Variation In Your ChIP

    Active Motif has developed a ChIP Normalization Strategy that can be used to normalize ChIP qPCR and ChIP-Seq data to reduce the effects of technical variation and sample processing bias. This normalization strategy can be applied across samples and antibodies. More >

  • RIME Service: Identify Protein Interactions by Mass Spectrometry

    Adding to our growing list of Epigenetic Services offerings, Active Motif now offers RIME (Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins), which allows for the identification of transcriptional co-factors and chromatin associated proteins. More >

  • Low Cell Number ChIP-Sequencing Services

    New advancements in our ChIP-Seq protocols and pipeline have reduced ChIP-Seq starting material requirements by 1,000 fold! In large contrast to the 10,000,000 cell requirement needed to perform standard ChIP-Seq, Active Motif now offers low cell number ChIP-Seq services, that allow you to perform ChIP-Seq with as few as 10,000 cells. More >

  • New Recombinant Nucleosomes for use in Enzymatic Assays and Chromatin Assembly

    Active Motif's Recombinant Nucleosomes offer a more biologically relevant choice of substrate when compared to histone proteins alone or synthetic peptides for use in drug discovery screening, analyzing enzyme kinetics or monitoring changes in histone modifications. Each recombinant nucleosome is comprised of octamers of unmodified core histone proteins (H2A, H2B, H3 and H4) bound by DNA. Biotin-tagged Nucleosomes are also available for pull-down or binding assays. More >

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