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Tools to analyze nuclear function,
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Gene Regulation

Gene Regulation

study both transcriptional & post-transcriptional regulation

Though gene regulation studies have historically focused on transcription, gene expression is controlled at both the transcriptional and post-transcriptional levels. Transcription factors and other DNA-binding proteins modulate when, where and how much of a gene’s mRNA is transcribed, while microRNAs and the RISC complex interact with the 3´UTR of gene transcripts to control the stability of an mRNA and its translation into protein. In addition, because DNA is packaged as nucleosomes, histone modifications and DNA methylation play a large regulatory role by altering chromatin structure, which influences whether or not the DNA is accessible for transcription.

Transcriptional Regulation

Transcriptional Regulation

Active Motif provides a wide range of products and services for transcriptional regulation research including Transcription Factor Activity Assays and over 18,000 pre-cloned human promoters and transcription factor response elements. Learn More >

Post Transcriptional Regulation

Post-Transcriptional Regulation

Active Motif provides a wide range of products and services for transcriptional regulation research including Transcription Factor Activity Assays and over 18,000 pre-cloned human promoters and transcription factor response elements. Learn More >