Romidepsin
Aliases: Romidepsin, FK228, FK 228, FR901228, Depsipeptide |
Catalog No: 14082 | Format: 5 mg | ¥45,000 | Buy |
Catalog No: 14083 | Format: 1 mg | ¥15,000 | Buy |
Application: Histone Acetylation (HAT & HDAC) |
Chemical Properties
MW = 540.7
C24H36N4O6S2
CAS 128517-07-7
>98% (HPLC); NMR (Conforms)
Description
A potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6 respectively (ref 1). Induces apoptosis in a variety of cell lines (ref 2) and displays anti-tumor activity in mouse models (ref 3). Recently approved for clinical uses in T-cell lymphoma (ref 4).
Contents
Colorless lyophilized wax (vials appear empty). May be dissolved in DMSO (10 mg/ml).
Storage Conditions
Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month.
References
1. R Furumai et al. Cancer Res. 2002, 62:4916
2. J Panicker et al. Cell Cycle 2010, 9:1830
3. H Ueda et al. J. Antibiot. (Tokyo) 1994, 47:315
4. MK VanderMolin et al. J. Antibiot. (Tokyo) 2011, 64:525