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Daminozide
| Aliases: 1-(2,2-Dimethylhydrazide)butanedioic acid; N-(dimethylamino)succinamic acid |
| 商品コード: 14058 | Format: 250 mg | ¥34,000 | Buy |
| 商品コード: 14059 | Format: 50 mg | ¥12,000 | Buy |
| Application: Histone Methylation (HMT & HDM) |
Chemical Properties
MW = 160.2
C6H12N2O3
CAS 1596-84-5
MP = 158-162°C
>98% (TLC); NMR (Conforms)
Description
A selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50 = 1.5, 0.55 and 2.1 µM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50 > 100 M (ref 1).
Contents
White powder. May be dissolved in DMSO (50 mg/ml); Water (20 mg/ml, warm).
Storage Conditions
Store desiccated as supplied at room temperature for up to 3 years. Store solutions at -20°C for up to 3 months.
References
1. NR Rose et al. J. Med. Chem. 2012, 55:6639
Chemical structure of Daminozide.
